Worst Pills
drospirenone and ethinyl estradiol (GIANVI, YASMIN, YAZ, ZARAH)

Drug and Dietary Supplement Profiles

A comprehensive review of the safety and effectiveness of this drug. If the drug is not a Do Not Use product, information on adverse effects, drug interactions and how to use the medication are included.
Search results below include drug profiles where your selected drug is a primary subject of discussion

Disease and Drug Family Information

Search results below include Disease and Drug Family Information where your selected drug is a primary subject of discussion
  • Oral Contraceptives [hide all summaries]
    The pill can cause many adverse effects. Some of them are merely a nuisance, while others can be life-threatening. The pill can cause headaches, bloating, nausea, irregular bleeding and spotting, breast tenderness, weight gain, or vision changes. Other more serious adverse effects that can occur from a few months to a few years after starting oral contraceptives include high blood pressure, gallbladder disease, liver tumors, depression, and metabolic disorders, such as diabetes. Temporary infertility has been associated with the period of time right after pill use is stopped. But the two most dangerous risks associated with taking birth control pills are blood clots and cancer.

Worst Pills, Best Pills Newsletter Articles

Search results below include Worst Pills, Best Pills Newsletter Articles where your selected drug is a primary subject of discussion
  • Drugs That Cause Weight Gain [hide all summaries]
    (December 2017)
    Weight gain is an adverse event associated with many widely used medications and may lead to significant overweight and obesity, especially in susceptible individuals. Find out which drugs have this adverse effect.
  • Oral Contraceptives Containing Drospirenone - Increased Risk of Blood Clots [hide all summaries]
    (May 2011)
    This article reviews recent studies showing significantly increased risk of blood clots in high-selling contraceptives containing drospirenone, compared to the lower risk of blood clots with older contraceptives containing levonorgestrel. Drospirenone is an ingredient in the contraceptive pills Yaz and Yasmin, which are sold in the U.S.
  • Think Twice About Third-Generation Oral Contraceptives and YASMIN [hide all summaries]
    (December 2009)
    Two large new studies shed light on the increased risks of so-called "third generation" oral contraceptives containing desogestrel as well as oral contraceptives containing drospirenone (such as YASMIN and YAZ) compared to older, "second-generation" oral contraceptives. This study also discusses newly discovered risks associated with YASMIN and YAZ.
  • FDA Issues New Warnings For Muscle Spasm Drug Tizanidine (ZANAFLEX) [hide all summaries]
    (August 2007)
    The muscle spasm drug tizanidine (ZANAFLEX) combined with certain other drugs could cause serious complications such as drowsiness and can dramatically lower blood pressure, according to the Food and Drug Administration (FDA). The article lists 20 drugs to avoid if you are using Zanaflex so that you avoid these potentially dangerous interactions.
  • Cutting Your Drug Bill While Reducing Your Risk Of Avoidable Adverse Drug Reactions: Six Examples [hide all summaries]
    (February 2005)
    This article will look at the potential savings for the individual consumer if the alternative treatments recommended in Worst Pills, Best Pills were used for six DO NOT USE drugs. All six are listed in the Drug Topics Magazine Top 200 selling drugs in U.S. in 2003. The drugs are: celecoxib (CELEBREX) used for arthritis and pain; the Alzheimer’s disease drug donepezil (ARICEPT); drospirenone with ethinyl estradiol (YASMIN 28), an oral contraceptive; esomeprazole (NEXIUM) the “new purple pill” for heartburn; montelukast (SINGULAIR), a drug approved for both asthma and hay fever; and valdecoxib (BEXTRA), an arthritis drug very similar to celecoxib.The combined sales of these six DO NOT USE drugs was $8.1 billion with more that 75 million prescriptions dispensed in 2003.
  • Do Not Use! Reports of Blood Clots With the Use of the Oral Contraceptive Drospirenone With Ethinyl Estradiol (YASMIN) [hide all summaries]
    (May 2003)
    You should not use Yasmin for the reasons we stated in the April 2002 newsletter. Some physicians may believe that Yasmin is less likely to cause blood clots than older oral contraceptives; however, there is no research to support such a belief.
  • Do Not Use! The New Birth Control Pill Drospirenone With Ethinyl Estradiol (YASMIN) [hide all summaries]
    (April 2002)
    The combination birth control pill of ethinyl estradiol with drospirenone (YASMIN) was approved by the Food and Drug Administration (FDA) in April 2001. Combination birth control pills contain the hormones estrogen and progestin. There is no medical reason that you should be using Yasmin rather than one of the older pills containing the progestins norgestrel, levonorgestrel or norethindrone.

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