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November 2024
The oral drugs valproic acid (generics only) and divalproex (DEPAKOTE and generics) are used to treat certain kinds of seizures. Children born to mothers who took valproate drugs during pregnancy have higher risks of reduced intelligence and birth defects. A new post-marketing study suggests an increased risk of neurodevelopmental disorders (mental or developmental disorders that begin in early childhood) in children of fathers treated with valproate drugs during the three months prior to conception.
November 2018
Find out why women of child-bearing age should avoid taking valproate for migraines and should use it only for seizure or bipolar disorder if other medicines fail to adequately control these conditions or cause unacceptable adverse effects.
December 2017
Weight gain is an adverse event associated with many widely used medications and may lead to significant overweight and obesity, especially in susceptible individuals. Find out which drugs have this adverse effect.
March 2017
Bipolar disorder, also known as manic depression, is a serious chronic mental illness that afflicts approximately 5.4 million people in the U.S. In this article, we review the benefits and safety of several drugs that are commonly used to treat this disorder.
November 2008
Among patients taking antiepileptic drugs for epilepsy, the risk of suicidal thinking and behavior was 3.5 times greater compared to placebo. These drugs are also used to treat pain and as mood stabilizers in people with manic-depressive disorders.
Pay attention to common warning signs that may indicate an increased risk of suicide, including: talking or thinking about hurting oneself or ending one’s life; withdrawal from family and friends; worsening depression; increased preoccupation with death and dying; giving away prized possessions. Do not make any medication regimen changes without consulting your provider. Unsupervised sudden changes in prescription drugs can have dangerous adverse effects
March 2001
The editors of the highly respected Medical Letter on Drugs and Therapeutics, for doctors and pharmacists, reviewed evidence from controlled clinical trials of anti-seizure drugs for psychiatric disorders in the December 11, 2000 issue. Controlled clinical trials are the “gold standard” for testing the effectiveness of drugs.
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