Worst Pills
methadone (DOLOPHINE, METHADOSE)

Drug and Dietary Supplement Profiles

A comprehensive review of the safety and effectiveness of this drug. If the drug is not a Do Not Use product, information on adverse effects, drug interactions and how to use the medication are included.
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Disease and Drug Family Information

Search results below include Disease and Drug Family Information where your selected drug is a primary subject of discussion
  • Opioids [hide all summaries]
    Most of the time when someone is able to swallow, they should first try a non-opioid drug such as aspirin taken by mouth. If aspirin alone is not effective, it can be combined with an opioid, such as codeine. These two drugs work in different ways, and when they are used together, they generally relieve pain that would otherwise require a higher dose of an opioid, while causing fewer adverse effects.

Worst Pills, Best Pills Newsletter Articles

Search results below include Worst Pills, Best Pills Newsletter Articles where your selected drug is a primary subject of discussion
  • FDA Should Change Labels On Opioid Painkillers to Deter Misprescribing [hide all summaries]
    (September 2012)
    The article reviews a recent petition to the FDA seeking improvements on the labels of prescription opioids (narcotics). The label change would prevent drug companies from promoting these drugs for noncancer pain for dangerously long periods of time, at doses that are too high, and for uses other than severe pain in noncancer patients. The petition was signed by 37 public health experts, including leaders in the fields of pain medicine, addiction and primary care; the health commissioners of New York City and New York state; and Dr. Sidney Wolfe, director of Public Citizen’s Health Research Group.
  • Oxycodone: Be Careful What You Take With It [hide all summaries]
    (September 2009)
    The article lists 24 drugs that can increase the toxicity of oxycodone if taken together with the drug and 11 other drugs that can weaken its effectiveness as a painkiller if they are simutaneously used.
  • Methadone for Pain [hide all summaries]
    (May 2007)
    A few months ago the FDA warned about the potential of methadone - when used to treat pain - to cause life-threatening breathing problems and heart rhythm disturbances. When it made this safety announcement, however, the FDA negligently failed to point out that they had recommended a drastic reduction in the starting dose for pain to prevent some of these life-threatening adverse reactions. The new recommended starting dose is more than a 2.5 fold reduction in the dosage for the initial treatment of pain. Symptoms of overdose with the older, higher doses are discussed in the article.
  • Life-Threatening Adverse Effects and Deaths Reported in Patients Using Methadone (DOLOPHINE) for Pain Relief [hide all summaries]
    (February 2007)
    Deaths, cardiac and respiratory, have been reported during initiation and conversion of pain patients to methadone treatment from treatment with other opioid agonists. Because methadone has some of the effects of other narcotics, do not stop the drug without consulting the prescriber because of the possibility of serious and uncomfortable withdrawal symptoms.

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