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imipramine (TOFRANIL, TOFRANIL PM)

Drug and Dietary Supplement Profiles

A comprehensive review of the safety and effectiveness of this drug. If the drug is not a Do Not Use product, information on adverse effects, drug interactions and how to use the medication are included.
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Disease and Drug Family Information

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Worst Pills, Best Pills Newsletter Articles

Search results below include Worst Pills, Best Pills Newsletter Articles where your selected drug is a primary subject of discussion
  • Anticholinergics May Increase Dementia Risk in Elderly [hide all summaries]
    (August 2015)
    Learn about recent evidence suggesting that anticholinergic drugs — which include many antidepressants, antihistamines and overactive bladder control medications — may increase the risk for developing Alzheimer’s disease and other types of dementia in the elderly.
  • How Effective Are Antidepressants for Depression? [hide all summaries]
    (February 2014)
    Some degrees of depression are less likely to respond to treatment with an antidepressant. This article reviews the evidence and evaluates 27 different antidepressants, labeling many as Do Not Use or Limited Use.
  • Antidepressants and Dementia in the Elderly [hide all summaries]
    (August 2012)
    We review a recent study concerning the lack of evidence that antidepressants are effective in elderly, demented people. Find out the risks involved with antidepressant use in this population and learn about the safer, more effective nondrug approaches to treating depression in elderly adults.
  • Preventing Heat-Induced Death and Illness [hide all summaries]
    (June 2012)
    This article lists practical steps to take to avoid death, hospitalization or other medical problems caused by heat stress. It also contains a list of 123 drugs that can impair your response to heat.
  • Neuroleptic Malignant Syndrome (NMS) [hide all summaries]
    (December 2010)
    The article describes the symptoms of the life-threatening neurological disorder neuroleptic malignant syndrome (NMS) and lists 40 different prescription drugs that have been found to cause it.
  • Drug-Induced Parkinsonism [hide all summaries]
    (October 2010)
    A study discovered that more than 1 out of every 10 people who went to a Parkinson’s disease center was found to have drug-induced Parkinsonism. These people were misdiagnosed as having the more common illness, Parkinson’s disease, which is irreversible and has unknown causes.
  • Dextromethorphan (DELSYM, ROBITUSSIN DM) for Cough: More Reasons to Avoid It [hide all summaries]
    (June 2010)
    Find out why you should not use cough products such as ROBITUSSIN DM that contain dextromethorphan. Also view a list of 22 other drugs that can have harmful interactions with dextromethorphan.
  • Colchicine Interactions with Other Drugs Can Be Life-Threatening [hide all summaries]
    (December 2008)
    This article lists 27 drugs that can have life-threatening interactions with the widely-used gout drug, colchicine, resulting in dangerously elevated levels of colchicine. Too much colchicine in the body leads to toxicity such as fever, vomiting, diarrhea, abdominal pain and muscle pains. Even worse, it can impair the bone marrow’s ability to make red and white blood cells, causing severe anemia and dangerously low numbers of white blood cells. When the number of white blood cells is reduced, your body may have difficulty fighting infections. Most people who have died from colchicine toxicity have had bone marrow toxicity or had preexisting kidney problems. Every patient on colchicine — whether on other drugs or not — should be alert for evidence of colchicine toxicity as described above.
  • New Report Sheds Light on Serious Safety Problems with Anti-Smoking Drug Varenicline (CHANTIX) [hide all summaries]
    (July 2008)
    A recent study has found large numbers of reports of psychiatric adverse effects with varenicline (CHANTIX) including hundres of reports of suicidal acts, thoughts or behaviors; possible psychosis; and hostility or aggression.
  • Serotonin Syndrome Due to Drug Interactions [hide all summaries]
    (April 2008)
    The article lists more than 30 prescription drugs that can cause the serotonin syndrome.
  • FDA: All Antidepressants Should Carry Warnings About Risks of Suicidal Thoughts in Young Adults [hide all summaries]
    (July 2007)
    Because of new information about increased risks of suicidal thoughts associated with the use of a variety of antidepressants, people of all ages should be monitored closely with all antidepressants after the drugs are first prescribed, switched or when the dosage is changed. Do not stop using any antidepressants without first consulting the prescriber.
  • Black Box Warning To Be Required On All Antidepressants Concerning Suicide Risk In Children And Adolescents [hide all summaries]
    (December 2004)
    Belatedly, the Food and Drug Administration (FDA) announced on October 15, 2004 that it is taking steps to inform parents and physicians about the risks of antidepressants when these drugs are used to treat major depressive disorder in children and adolescents.
  • Drug Induced Psychiatric Symptoms [hide all summaries]
    (October 2002)
    This is the first of a two part series on drug induced psychiatric symptoms that is based on the July 8, 2002 issue of The Medical Letter on Drugs and Therapeutics. Regular readers of Worst Pills, Best Pills News will recognize The Medical Letter as a reference source written for physicians and pharmacists that we often use because of its reputation as an objective and independent source of drug information. The article lists the drugs and their psychiatric adverse effects.

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